9. Categorical Weight Loss at Week 52 in Patients Who Lost >3% of Body Weight at Week 12 (n=735)
This slide shows the effectiveness of sustained, significant weight loss in patients treated with XENICAL plus diet in clinical trials. Of patients treated with XENICAL plus diet, 69.1% lost >3% of initial body weight by week 12. Mean weight loss at week 12 was 13 lbs and at week 52 was 19 lbs (pooled data from five clinical trials). And at week 52, of patients who lost >3% by week 12, 27.5% had lost less than 5%, 35.2% had lost between 5% and 10%, 21.6% lost between 10% and 15%, and 15.7% lost 15% or more. These numbers suggest that early success with XENICAL plus diet may lead to significant long-term weight loss.
10. Mean Percent Change in LDL Cholesterol in At-Risk Population (>130 mg/dL)
In patients losing similar amounts of weight, the decrease in LDL cholesterol seen in those treated with XENICAL plus diet was consistently greater than the decrease in those treated with placebo plus diet. This graph depicts the mean percent change in LDL cholesterol with respect to weight loss in those patients who entered the trials with abnormal LDL cholesterol levels and who completed 1 year of treatment with XENICAL plus diet or placebo plus diet.
